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Regeneron Collaborates with Alnylam to Discover- Develop and Commercialize RNAi Therapeutics for Ophthalmic and CNS Disorders

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Regeneron Collaborates with Alnylam to Discover- Develop and Commercialize RNAi Therapeutics for Ophthalmic and CNS Disorders

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  • Alnylam & Regeneron to co-discover RNAi therapies for eye and CNS diseases. Alnylam to receive $400M upfront- $400M equity at a price of $90/share- $200M as milestones and royalties on sales of products. Regeneron to get rights to develop & commercialize candidates for ocular diseases and to jointly lead CNS diseases program with an option to candidate selection with equal profit sharing
  • The companies also target genes expressed in the liver including the evaluation of Regeneron's P-I pozelimab (REGN3918) and Alnylam's P-II cemdisiran. Regeneron to lead the combination’s development while Alnylam to take care of monothx with no changes in 2018 deal for NASH
  • The companies collaborate for 5yrs involving 30 targets with an option to extend. Alnylam to receive $2.5M at the initiation of each program and $2.5M at the identification of lead candidates with $30M as annual discovery funding for each target

Ref: Alnylam | Image: Behance

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